Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.8 extracted from

  • Shepherd, D.L.; Hathaway, Q.A.; Pinti, M.V.; Nichols, C.E.; Durr, A.J.; Sreekumar, S.; Hughes, K.M.; Stine, S.M.; Martinez, I.; Hollander, J.M.
    Exploring the mitochondrial microRNA import pathway through polynucleotide phosphorylase (PNPase) (2017), J. Mol. Cell. Cardiol., 110, 15-25 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.8

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TCS8
-
-
Mus musculus Q8K1R3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-
heart
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
PNPT1
-
 Homo sapiens
PNPT1
-
 Mus musculus

General Information

General Information Comment Organism
physiological function in cardiac tissue from human and mouse models of type 2 diabetes mellitus, levels of Argonaute2 protein, associated with cytosolic and mitochondrial miRNAs, are unchanged while PNPase protein expression levels are increased. There an increase in the association between both proteins in the diabetic state Homo sapiens
physiological function PNPase is a contributor to mitochondrial miRNA import through the transport of miRNA-378, which may regulate bioenergetics during type 2 diabetes mellitus. In cardiac tissue from human and mouse models of type 2 diabetes mellitus, levels of Argonaute2 protein, associated with cytosolic and mitochondrial miRNAs, are unchanged while PNPase protein expression levels are increased. There an increase in the association between both proteins in the diabetic state. miRNA-378 is significantly increased in db/db mice, leading to decrements in ATP6 levels and ATP synthase activity, which is also exhibited when overexpressing PNPase in HL-1 cardiomyocytes Mus musculus